The Emirillia Chronicles by Michael Chatfield (incidentally my favorite litrpg author), the writer of the Ten Realms series, is one of the more fascinating ones I've come across. Unlike the Ten Realms, which is fairly unfocused due to Erik and Rugrat's generalized motivations based on their personal ethics, desires, and whims, Emirillia has a somewhat clearer goal for the characters.
In the series, humanity was defeated by an alien empire called the Jukal, but the Jukal almost lost everything in the process. Humanity's innovative and competitive nature made them devastating opponents, despite their lower tech base, so the Jukal decided to destroy them utterly... until one of them, a scientist named Lok'al, came up with the idea of tricking special-grown humans into killing more aggressive species for them.
What they came up with is the Trapped Mind Project, where 'cycles' of people grown in a simulation of Earth, believing they are 'logging in' to a VRMMO, are physically manifested on the planet and sent against aggressive species. Natives of Emirillia are also human variants, made by tweaking DNA to make them seem like the legendary races (dwarves, gnomes, elves, demons, angels, dragons, etc). By the time the protagonist, Austin Zane, 'logs in', over eight hundred years have passed and Emirillia has become something of a reality TV show for the Empire, used as the 'opiate of the masses'. Aggressive races that would have been exterminated previously are instead used as opponents for Players, and the POE (People of Emirillia) get caught in the crossfire, more often than not.
The protagonist is a brilliant engineer and scientist, a man who managed to exceed the parameters of the Earth simulation by creating a company that mined space and dumped the resources on Earth (something that normally didn't happen), and his desire to enter the 'game' was to build a cabin and get away from everything. Unfortunately for him, Bob (Lok'Al) has other plans, and Dave (as Austin comes to call himself) is too good-hearted and active by far to sit idly once he knows what is going on.
Generally speaking, much like the Ten Realms, this is a series for people who like to see the characters growing in power and helping others growing in power. It is also a series for those who like innovative and brilliant main characters (as the main ones are) and nasty characters getting their comeuppance. It is a rather large series (12 books), but I honestly hardly noticed the passing of time while I read it. This game has a significantly stronger western influence compared to the Ten Realms, which was more influenced by xianxia cultivation stories than anything else.